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Pentacyclic triterpenes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Autophagy (1) Caspase (1) Endogenous Metabolite (1) Keap1-Nrf2 (1) p38 MAPK (1) Parasite (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (7) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6601

Pomolic acid Randialic acid A	Apoptosis	Cancer
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

HY-N4165

Arnidiol

Others Others

Arnidiol is a pentacyclic triterpene isolated from Barleria Longiflora Linn F. .

Arnidiol	Others	Others
Arnidiol is a pentacyclic triterpene isolated from Barleria Longiflora Linn F. .

HY-145869

Anti-inflammatory agent 12	Others	Inflammation/Immunology
Anti-inflammatory agent 12 (Compound 2) is a pentacyclic triterpene compound. Anti-inflammatory agent 12 shows a significant bias in the LPS-induced inflammatory response with an IIC₅₀ value of 2.22 μM. Anti-inflammatory agent 12 has the potential for the research of inflammation disease .

HY-128366

Waltonitone	Apoptosis	Cancer
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo .

HY-145870

Anti-inflammatory agent 13	Others	Inflammation/Immunology
Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation .

HY-N0271

Echinocystic acid 1 Publications Verification	Reactive Oxygen Species Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Echinocystic acid is a natural pentacyclic triterpene with potent antioxidant, anti-inflammatory and analgesic activities .

HY-N12190

Centellasaponin A

Others Others

Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .
HY-N1037

δ-Amyrenone

Delta-Amyrone

δ-Amyrenone (Delta-Amyrone) is a pentacyclic triterpene compound from S. lineare, with anti-inflammatory effects .
HY-N1827

3-epi-Maslinic acid

3-epi-Maslinic acid is an acidic pentacyclic triterpene isolated from Hexane and dichloromethane extracts of Platostoma africanum P. Beauv .

Centellasaponin A	Others	Others
Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .

δ-Amyrenone Delta-Amyrone
δ-Amyrenone (Delta-Amyrone) is a pentacyclic triterpene compound from S. lineare, with anti-inflammatory effects .

3-epi-Maslinic acid
3-epi-Maslinic acid is an acidic pentacyclic triterpene isolated from Hexane and dichloromethane extracts of Platostoma africanum P. Beauv .

HY-N0568

Madecassoside Asiaticoside A	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase	Cardiovascular Disease Others Neurological Disease Inflammation/Immunology Endocrinology Cancer
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-N12225

Isoasiaticoside	Others	Neurological Disease
Isoasiaticoside is a pentacyclic triterpene saponin that can be isolated from Centella asiatica. Isoasiaticoside has potential neuroprotective effects in the 6-OHDA (HY-B1081)-induced PC12 cell model .

HY-N0194

Asiatic acid 2 Publications Verification	Apoptosis Parasite	Inflammation/Immunology Cancer
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-143456

Anti-inflammatory agent 18	Others	Inflammation/Immunology
Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC₅₀ of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .

HY-143457

Anti-inflammatory agent 19	Others	Inflammation/Immunology
Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC₅₀ of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .

Pomolic acid Randialic acid A	Triterpenes Euscaphis japonica other families Classification of Application Fields Staphyleaceae Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

Arnidiol	Triterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Disease Research Fields	Others
Arnidiol is a pentacyclic triterpene isolated from Barleria Longiflora Linn F. .

Echinocystic acid 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Gleditsia sinensis Lam. Plants Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis
Echinocystic acid is a natural pentacyclic triterpene with potent antioxidant, anti-inflammatory and analgesic activities .

Waltonitone	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo .

Centellasaponin A	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Plants Umbelliferae Vitex trifolia L. Saccharides	Others
Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .

Madecassoside Asiaticoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Plants Umbelliferae Vitex trifolia L. Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

Isoasiaticoside	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Plants Umbelliferae Vitex trifolia L. Saccharides	Others
Isoasiaticoside is a pentacyclic triterpene saponin that can be isolated from Centella asiatica. Isoasiaticoside has potential neuroprotective effects in the 6-OHDA (HY-B1081)-induced PC12 cell model .

Asiatic acid 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Umbelliferae Vitex trifolia L. Inflammation/Immunology Disease Research Fields	Apoptosis Parasite
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

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Pentacyclic triterpenes

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